VitaLabs Projects Up for Voting: Help Pick the Next Big Ideas
About VitaLabs
VitaLabs is VitaDAO's research program focused on finding new ways to improve health and extend life. It supports researchers with funding, mentorship, and resources to explore bold ideas that could change the way we think about aging.
Your Vote Matters
The VitaDAO community is now voting to choose four projects to receive:
Funding to carry out experiments.
Mentorship from top scientists.
Resources to help their ideas grow.
This is your chance to support the ideas you believe in! The voting process uses quadratic voting, which gives more weight to projects with broad support. If you hold Vita tokens, you can vote now on the Snapshot platform.
Projects to Vote On
This project seeks to characterize the key gene regulatory programs that drive a healthy aging brain toward pathological changes (such as deposition of senile plaques), especially via age- related neuroinflammation and microglial activation.
Genome dysregulation is a nearly universal characteristic of aging, largely due to increased transposable elements (TEs) activity. These DNA segments, which can move within the genome, constitute about 50% of our DNA, but aging research often focuses on the less than 1% that are coding regions.
Our team has developed a family of small molecules (analogs) that induce expression of hTERT in human cell lines, which in turn increases the amount and activity of telomerase. This would ideally involve two phases: testing 5 molecules in C. elegans and then mice.
The published literature suggests that inter-individual variability in regional brain aging dynamics can be mapped to gene variants, gene network architectures, and gene expression patterns, which can inform personalized interventions for the maintenance of brain health.
By leveraging single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and multi-omics data integration, we will systematically study the molecular mechanisms of stem cell aging; and identify novel targets and therapies to enhance their regenerative capacity.
Mapping and modulating telomere dynamics across tissues to uncover aging pathways and develop precision therapies for longevity and disease prevention
The project postulates extracellular matrix stiffening as the upstream cause of the hallmarks of aging and proposes leveraging generative AI to engineer matrix metalloproteinases capable of degrading sugar-modified, or glycated, collagen that resists normal remodeling.
Revive Synergy Longevity Labs is dedicated to extending healthspan by addressing cellular aging and systemic inflammation. We integrate AI-powered diagnostics, senolytic therapies, and microbiome interventions to target aging markers.
This project develops a computational model to predict biological age and identify mechanisms driving aging through single-sample gene co-expression networks. By analyzing GCN topology, we will identify biomarkers and transcriptional regulators linked to gene coordination loss.
The project aims to determine 2 to 5 target inserts for codon optimization and ligation into plasmid vectors for later development of animal cell line viability assay of accumulated therapeutic plant nutraceuticals.
Worlds first supplement line backed by numerous research studies with FDA/regulatory body approved health claims.
This project explores two approaches to radical life extension: GIGA (Get'em Growing Again) and MEGA (Make Genes Express Again). Using "synthetic vitality," we target synergistic drug combinations for greater lifespan impact than traditional methods.
Vote Now
You can help decide which projects get funding and support. If you hold Vita tokens, cast your vote now on Snapshot.
Your vote can make a difference!
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